Scurvy, About scurvy and healthy tips for it...
The vitamin C deficiency in scurvy disease
The vitamin C deficiency disease scurvy was formerly a common problem at the end of winter, when there had been no fresh fruit and vegetables for many months. Although there is no specific organ for storage of vitamin C in the body, signs of deficiency do not develop in previously adequately nourished subjects until they have been deprived of the vitamin for 4–6 months, by which time plasma and tissue concentrations have fallen considerably.
The earliest signs of scurvy in volunteers maintained on a vitamin C-free diet are skin changes, beginning with plugging of hair follicles by horny material, followed by enlargement of the hyperkeratotic follicles, and petechial hemorrhage with signifi cant extravasation of red cells, presumably as a result of the increased fragility of blood capillaries.
At a later stage there is also hemorrhage of the gums, beginning in the interdental papillae and rogressing to generalized sponginess and bleeding. This is frequently accompanied by secondary bacterial infection and considerable withdrawal of the gum from the necks of the teeth. As the condition progresses, there is loss of dental cement, and the teeth become loose in the alveolar bone and may be lost.
Wounds show only superfi cial healing in scurvy, with little or no formation of (collagen-rich) scar tissue, so that healing is delayed and wounds can readily be reopened. The scorbutic scar tissue has only about half the tensile strength of that normally formed.
Advanced scurvy is accompanied by intense pain in the bones, which can be attributed to changes in bone mineralization as a result of abnormal collagen synthesis. Bone formation ceases and the existing bone
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